Age-related macular degeneration (AMD) is one of the leading causes of irreversible vision impairment in people over the age of 60. This research focuses on semantic segmentation for AMD lesion detection in RGB fundus images, a non-invasive and cost-effective imaging technique. The results of the ADAM challenge - the most comprehensive AMD detection from RGB fundus images research competition and open dataset to date - serve as a benchmark for our evaluation. Taking the U-Net connectivity as a base of our framework, we evaluate and compare several approaches to improve the segmentation model's architecture and training pipeline, including pre-processing techniques, encoder (backbone) deep network types of varying complexity, and specialized loss functions to mitigate class imbalances on image and pixel levels. The main outcome of this research is the final configuration of the AMD detection framework, which outperforms all the prior ADAM challenge submissions on the multi-class segmentation of different AMD lesion types in non-invasive RGB fundus images. The source code used to conduct the experiments presented in this paper is made freely available.

Can Ukraine restore its pre-war borders? Why are Tomahawk missiles for Ukraine a'red line' for Russia? Is Russia testing NATO with aerial incursions in Europe? Lithuania, a small Baltic state bordering Belarus and Russia's Kaliningrad, is adapting to new tensions between NATO and Moscow. A member of the Lithuanian Riflemen's Union takes part in a military exercise in central Lithuania [Nils Adler/Al Jazeera] Two members of the Lithuanian Riflemen's Union take part in a military exercise in central Lithuania [Nils Adler/Al Jazeera] On a nearby building is an illuminated decorative Z, a symbol used to show support for the Russian military's full-scale invasion of Ukraine, which began in February 2022.

Plantar pressure mapping is essential in clinical diagnostics and sports science, yet large heterogeneous datasets often contain outliers from technical errors or procedural inconsistencies. Statistical Parametric Mapping (SPM) provides interpretable analyses but is sensitive to alignment and its capacity for robust outlier detection remains unclear. This study compares an SPM approach with an explainable machine learning (ML) approach to establish transparent quality-control pipelines for plantar pressure datasets. Data from multiple centers were annotated by expert consensus and enriched with synthetic anomalies resulting in 798 valid samples and 2000 outliers. We evaluated (i) a non-parametric, registration-dependent SPM approach and (ii) a convolutional neural network (CNN), explained using SHapley Additive exPlanations (SHAP). Performance was assessed via nested cross-validation; explanation quality via a semantic differential survey with domain experts. The ML model reached high accuracy and outperformed SPM, which misclassified clinically meaningful variations and missed true outliers. Experts perceived both SPM and SHAP explanations as clear, useful, and trustworthy, though SPM was assessed less complex. These findings highlight the complementary potential of SPM and explainable ML as approaches for automated outlier detection in plantar pressure data, and underscore the importance of explainability in translating complex model outputs into interpretable insights that can effectively inform decision-making.

Attention Deficit Hyperactivity Disorder (ADHD) is a common brain disorder in children that can persist into adulthood, affecting social, academic, and career life. Early diagnosis is crucial for managing these impacts on patients and the healthcare system but is often labor-intensive and time-consuming. This paper presents a novel method to improve ADHD diagnosis precision and timeliness by leveraging Deep Learning (DL) approaches and electroencephalogram (EEG) signals. We introduce ADHDeepNet, a DL model that utilizes comprehensive temporal-spatial characterization, attention modules, and explainability techniques optimized for EEG signals. ADHDeepNet integrates feature extraction and refinement processes to enhance ADHD diagnosis. The model was trained and validated on a dataset of 121 participants (61 ADHD, 60 Healthy Controls), employing nested cross-validation for robust performance. The proposed two-stage methodology uses a 10-fold cross-subject validation strategy. Initially, each iteration optimizes the model's hyper-parameters with inner 2-fold cross-validation. Then, Additive Gaussian Noise (AGN) with various standard deviations and magnification levels is applied for data augmentation. ADHDeepNet achieved 100% sensitivity and 99.17% accuracy in classifying ADHD/HC subjects. To clarify model explainability and identify key brain regions and frequency bands for ADHD diagnosis, we analyzed the learned weights and activation patterns of the model's primary layers. Additionally, t-distributed Stochastic Neighbor Embedding (t-SNE) visualized high-dimensional data, aiding in interpreting the model's decisions. This study highlights the potential of DL and EEG in enhancing ADHD diagnosis accuracy and efficiency.

The emergence of large language models (LLMs) has unlocked boundless possibilities, along with significant challenges. In response, we developed a mental health support chatbot designed to augment professional healthcare, with a strong emphasis on safe and meaningful application. Our approach involved rigorous evaluation, covering accuracy, empathy, trustworthiness, privacy, and bias. We employed a retrieval-augmented generation (RAG) framework, integrated prompt engineering, and fine-tuned a pre-trained model on novel datasets. The resulting system, Mentalic Net Conversational AI, achieved a BERT Score of 0.898, with other evaluation metrics falling within satisfactory ranges. We advocate for a human-in-the-loop approach and a long-term, responsible strategy in developing such transformative technologies, recognizing both their potential to change lives and the risks they may pose if not carefully managed.

Studying tissue samples obtained during autopsies is the gold standard when diagnosing the cause of death and for understanding disease pathophysiology. Recently, the interest in post mortem minimally invasive biopsies has grown which is a less destructive approach in comparison to an open autopsy and reduces the risk of infection. While manual biopsies under ultrasound guidance are more widely performed, robotic post mortem biopsies have been recently proposed. This approach can further reduce the risk of infection for physicians. However, planning of the procedure and control of the robot need to be efficient and usable. We explore a virtual reality setup with a digital twin to realize fully remote planning and control of robotic post mortem biopsies. The setup is evaluated with forensic pathologists in a usability study for three interaction methods. Furthermore, we evaluate clinical feasibility and evaluate the system with three human cadavers. Overall, 132 needle insertions were performed with an off-axis needle placement error of 5.30+-3.25 mm. Tissue samples were successfully biopsied and histopathologically verified. Users reported a very intuitive needle placement approach, indicating that the system is a promising, precise, and low-risk alternative to conventional approaches.

Cervical cancer is among the most commonly occurring cancer among women and claims a huge number of lives in low and middle-income countries despite being relatively easy to treat. Several studies have shown that public screening programs can bring down cervical cancer incidence and mortality rates significantly. While several screening tests are available, visual inspection with acetic acid (VIA) presents itself as the most viable option for low-resource settings due to the affordability and simplicity of performing the test. VIA requires a trained medical professional to interpret the test and is subjective in nature. Automating VIA using AI eliminates subjectivity and would allow shifting of the task to less trained health workers. Task shifting with AI would help further expedite screening programs in low-resource settings. In our work, we propose a lightweight deep learning algorithm that includes EfficientDet-Lite3 as the Region of Interest (ROI) detector and a MobileNet- V2 based model for classification. These models would be deployed on an android-based device that can operate remotely and provide almost instant results without the requirement of highly-trained medical professionals, labs, sophisticated infrastructure, or internet connectivity. The classification model gives an accuracy of 92.31%, a sensitivity of 98.24%, and a specificity of 88.37% on the test dataset and presents itself as a promising automated low-resource screening approach.

Using LLMs in a production environment presents security challenges that include vulnerabilities to jailbreaks and prompt injections, which can result in harmful outputs for humans or the enterprise. The challenge is amplified when working within a specific domain, as topics generally accepted for LLMs to address may be irrelevant to that field. These problems can be mitigated, for example, by fine-tuning large language models with domain-specific and security-focused data. However, these alone are insufficient, as jailbreak techniques evolve. Additionally, API-accessed models do not offer the flexibility needed to tailor behavior to industry-specific objectives, and in-context learning is not always sufficient or reliable. In response to these challenges, we introduce Archias, an expert model adept at distinguishing between in-domain and out-of-domain communications. Archias classifies user inquiries into several categories: in-domain (specifically for the automotive industry), malicious questions, price injections, prompt injections, and out-of-domain examples. Our methodology integrates outputs from the expert model (Archias) into prompts, which are then processed by the LLM to generate responses. This method increases the model's ability to understand the user's intention and give appropriate answers. Archias can be adjusted, fine-tuned, and used for many different purposes due to its small size. Therefore, it can be easily customized to the needs of any industry. To validate our approach, we created a benchmark dataset for the automotive industry. Furthermore, in the interest of advancing research and development, we release our benchmark dataset to the community.

Intraoperative fluorescent cardiac imaging enables quality control following coronary bypass grafting surgery. We can estimate local quantitative indicators, such as cardiac perfusion, by tracking local feature points. However, heart motion and significant fluctuations in image characteristics caused by vessel structural enrichment limit traditional tracking methods. We propose a particle filtering tracker based on cyclicconsistency checks to robustly track particles sampled to follow target landmarks. Our method tracks 117 targets simultaneously at 25.4 fps, allowing real-time estimates during interventions. It achieves a tracking error of (5.00 +/- 0.22 px) and outperforms other deep learning trackers (22.3 +/- 1.1 px) and conventional trackers (58.1 +/- 27.1 px).

Retrieval-Augmented Generation (RAG) represents a major advancement in natural language processing (NLP), combining large language models (LLMs) with information retrieval systems to enhance factual grounding, accuracy, and contextual relevance. This paper presents a comprehensive systematic review of RAG, tracing its evolution from early developments in open domain question answering to recent state-of-the-art implementations across diverse applications. The review begins by outlining the motivations behind RAG, particularly its ability to mitigate hallucinations and outdated knowledge in parametric models. Core technical components-retrieval mechanisms, sequence-to-sequence generation models, and fusion strategies are examined in detail. A year-by-year analysis highlights key milestones and research trends, providing insight into RAG's rapid growth. The paper further explores the deployment of RAG in enterprise systems, addressing practical challenges related to retrieval of proprietary data, security, and scalability. A comparative evaluation of RAG implementations is conducted, benchmarking performance on retrieval accuracy, generation fluency, latency, and computational efficiency. Persistent challenges such as retrieval quality, privacy concerns, and integration overhead are critically assessed. Finally, the review highlights emerging solutions, including hybrid retrieval approaches, privacy-preserving techniques, optimized fusion strategies, and agentic RAG architectures. These innovations point toward a future of more reliable, efficient, and context-aware knowledge-intensive NLP systems.